Human Metapneumovirus as a Cause of Severe Respiratory Illness in the Second Trimester of Pregnancy: Two Cases

Abstract

Despite being a fairly common cause of respiratory infection in adults, there have been few reported cases of human metapneumovirus (hMPV) in pregnancy. Other viruses, such as influenza, have been heavily reported on, and it is well established that these illnesses are detrimental to the pregnant population. However, we currently have limited data about hMPV’s effect. First, we discuss the case of a patient who presented to the emergency department in the second trimester with severe shortness of breath and was ultimately diagnosed with hMPV. Second, we discuss the case of a patient who presented as an intensive care unit transfer in the second trimester in severe respiratory distress with a positive test for hMPV at the outside facility. These cases highlight the fact that inpatient management might be needed to treat hMPV in pregnant patients, even for those without a significant prior respiratory medical history. Given the limited number of published cases of hMPV in the antepartum patient population, we hope to provide guidance for management of such cases and highlight the importance of prompt diagnosis in pregnant populations.