J Clin Gynecol Obstet

Journal of Clinical Gynecology and Obstetrics, ISSN 1927-1271 print, 1927-128X online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Gynecol Obstet and Elmer Press Inc

Journal website https://jcgo.elmerpub.com

Original Article

Volume 15, Number 2, June 2026, pages 62-68

Does Office Hysteroscopy Add Value in Polycystic Ovary Syndrome Patients With Normal Transvaginal Ultrasound Findings?

↓ **Table 1.** Demographic Data in Both Groups
	Group A (n = 100)	Group B (n = 50)	P value
BMI: body mass index; SD: standard deviation.
Age (years), mean ± SD	28.94 ± 4.62	26.86 ± 3.71	0.224
Weight (kg), mean ± SD	73.33 ± 11.66	67.36 ± 12.50	< 0.005
Height (cm), mean ± SD	158.17 ± 28.5	161.30 ± 6.98	0.447
BMI (kg/m²), mean ± SD	27.51 ± 3.53	25.80 ± 4.03	< 0.008
Education
Illiterate	41 (41.0%)	23 (46.0%)
Primary school	23 (23.0%)	14 (28.0%)	0.665
Secondary school	27 (27.0%)	11 (22.0%)
High level	9 (9.0%)	2 (4.0%)
Infertility
Primary	72 (72.0%)	33 (66.0%)	0.284
Secondary	28 (28.0%)	17 (34.0%)
Medication
No	87 (87.0%)	50 (100%)
Metformin 850 mg XR (sustained release)	5 (5.0%)	0	< 0.01
Metformin 500 mg	5 (5.0%)	0
Clomiphene citrate	3 (3.0%)	0
Parity
0	72 (72.0%)	33 (66.0%)
1	15 (15.0%)	13 (26.0%)	0.434
2	11 (11.0%)	3 (6.0%)
3	2 (2.0%)	1 (2.0%)
Duration of infertility, mean ± SD	4.87 ± 2.39	4.25 ± 2.43	0.139

↓ Table 1. Demographic Data in Both Groups

Group A (n = 100)

Group B (n = 50)

P value

BMI: body mass index; SD: standard deviation.

Age (years), mean ± SD

28.94 ± 4.62

26.86 ± 3.71

0.224

Weight (kg), mean ± SD

73.33 ± 11.66

67.36 ± 12.50

< 0.005

Height (cm), mean ± SD

158.17 ± 28.5

161.30 ± 6.98

0.447

BMI (kg/m²), mean ± SD

27.51 ± 3.53

25.80 ± 4.03

< 0.008

Education

Illiterate

41 (41.0%)

23 (46.0%)

Primary school

23 (23.0%)

14 (28.0%)

0.665

Secondary school

27 (27.0%)

11 (22.0%)

High level

9 (9.0%)

2 (4.0%)

Infertility

Primary

72 (72.0%)

33 (66.0%)

0.284

Secondary

28 (28.0%)

17 (34.0%)

Medication

87 (87.0%)

50 (100%)

Metformin 850 mg XR (sustained release)

5 (5.0%)

< 0.01

Metformin 500 mg

5 (5.0%)

Clomiphene citrate

3 (3.0%)

Parity

72 (72.0%)

33 (66.0%)

15 (15.0%)

13 (26.0%)

0.434

11 (11.0%)

3 (6.0%)

2 (2.0%)

1 (2.0%)

Duration of infertility, mean ± SD

4.87 ± 2.39

4.25 ± 2.43

0.139

↓ **Table 2.** Hormonal Profile in Study Groups
	Group A (n = 100)	Group B (n = 50)	P value
TSH: thyroid-stimulating hormone; FSH: follicle-stimulating hormone; LH: luteinizing hormone; SD: standard deviation.
TSH, mean ± SD	2.88 ± 1.56	2.75 ± 1.1	0.621
Prolactin, mean ± SD	13.19 ± 6.11	12.25 ± 6.31	0.388
LH, mean ± SD	8.85 ± 3.015	4.94 ± 2.29	< 0.000
FSH, mean ± SD	7.34 ± 3.35	5.82 ± 2.24	< 0.001

↓ Table 2. Hormonal Profile in Study Groups

Group A (n = 100)

Group B (n = 50)

P value

TSH: thyroid-stimulating hormone; FSH: follicle-stimulating hormone; LH: luteinizing hormone; SD: standard deviation.

TSH, mean ± SD

2.88 ± 1.56

2.75 ± 1.1

0.621

Prolactin, mean ± SD

13.19 ± 6.11

12.25 ± 6.31

0.388

LH, mean ± SD

8.85 ± 3.015

4.94 ± 2.29

< 0.000

FSH, mean ± SD

7.34 ± 3.35

5.82 ± 2.24

< 0.001

↓ **Table 3.** Hysteroscopic Findings in Study Groups
	Group A (n = 100)	Group B (n = 50)	P value
Cervical canal
Normal	91 (91.0%)	47 (94.0%)	0.495
Thick mucosal secretion	6 (6.0%)	3 (6.0%)
Ectopy (ectocervix)	3 (3.0%)	0
Endometrium
Normal	94 (94.0%)	46 (92.0%)
Thin	4 (4.0%)	4 (8.0%)	0.569
Focal lesions
Micropolyps	1 (1.0%)	0
Morphological anomalies
Subseptate uterus	1 (1.0%)	0
Endometrial vasculature
Normal	89 (89.0%)	42 (84.0%)
Pale	7 (7.0%)	7 (14.0%)	0.325
Congested	4 (4.0%)	1 (2.0%)
Darwish triad
Normal	94 (94%)	76 (92%)	0.325
Intratubal micropolyps	6 (6%)	4 (8%)

↓ Table 3. Hysteroscopic Findings in Study Groups

Group A (n = 100)

Group B (n = 50)

P value

Cervical canal

Normal

91 (91.0%)

47 (94.0%)

0.495

Thick mucosal secretion

6 (6.0%)

3 (6.0%)

Ectopy (ectocervix)

3 (3.0%)

Endometrium

Normal

94 (94.0%)

46 (92.0%)

Thin

4 (4.0%)

4 (8.0%)

0.569

Focal lesions

Micropolyps

1 (1.0%)

Morphological anomalies

Subseptate uterus

1 (1.0%)

Endometrial vasculature

Normal

89 (89.0%)

42 (84.0%)

Pale

7 (7.0%)

7 (14.0%)

0.325

Congested

4 (4.0%)

1 (2.0%)

Darwish triad

Normal

94 (94%)

76 (92%)

0.325

Intratubal micropolyps

6 (6%)

4 (8%)

↓ **Table 4.** Histopathologic Findings in Both Groups
	Group A (n = 100)	Group B (n = 50)	P value
Proliferative endometrium	76 (76.0%)	42 (84.0%)
Chronic endometritis	7 (14%)	4 (8%)
Distorted proliferative endometrium	8 (16%)	0	0.239
Microscopic polypi	7 (7.0%)	4 (8.0%)
Simple hyperplasia	2 (2%)	0

↓ Table 4. Histopathologic Findings in Both Groups

Group A (n = 100)

Group B (n = 50)

P value

Proliferative endometrium

76 (76.0%)

42 (84.0%)

Chronic endometritis

7 (14%)

4 (8%)

Distorted proliferative endometrium

8 (16%)

0.239

Microscopic polypi

7 (7.0%)

4 (8.0%)

Simple hyperplasia

2 (2%)

↓ **Table 5.** Diagnostic Indices of Office Hysteroscopy Versus Histopathology in Both Groups
	Group A (n = 100)	Group B (n = 50)
PPV: positive predictive value; NPV: negative predictive value.
Sensitivity	100%	93.50%
Specificity	100%	100%
PPV	94%	91.48%
NPP	0	6.50%

↓ Table 5. Diagnostic Indices of Office Hysteroscopy Versus Histopathology in Both Groups

Group A (n = 100)

Group B (n = 50)

PPV: positive predictive value; NPV: negative predictive value.

Sensitivity

100%

93.50%

Specificity

100%

PPV

94%

91.48%

NPP

6.50%